The DNA and RNA surveillance systems in cells ensure faithful transmission and expression of genetic information, which is essential for the survival and well-being of all living organisms. These systems guard against external and internal insults on the genome and transcriptome by repairing damaged DNA structures or by eliminating aberrant RNA molecules. Defects in these systems could lead to alterations in the fate and functions of the cell and many human diseases. A prominent example is cancer, which is characterized by genomic instability, aberrant gene expression and uncontrolled proliferation. 


The research in our laboratory is centered on the cellular responses to DNA double-strand break damage and replication obstruction. We also investigate the role of RNA surveillance and metabolism in these stress responses, focusing on the nonsense-mediated RNA decay (NMD) pathway. A combination of cell biological, biochemical and imaging    approaches and techniques is employed to decipher key mechanisms of the DNA/RNA surveillance networks with the goal to improve the understanding and treatment of cancer.




Funding:


Program Affiliations:

DNA and RNA Surveillance Systems:

Relations to Cancer

Department of Cell Biology and Physiologyhttp://www.cellbiology.wustl.edu/http://cellbio.wustl.edu/shapeimage_2_link_0
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