DNA and RNA Surveillance Systems:

Relations to Cancer

The DNA and RNA surveillance systems in cells plays a pivotal role in ensuring the faithful transmission and expression of genetic information, a cornerstone for the survival and well-being of all living organisms. These systems guard against external and internal insults on the genome and transcriptome by repairing damaged DNA structures or by eliminating faulty RNA molecules. Defects in these systems can alter the functions of the cell and cause many human diseases. A prominent example is cancer, which is characterized by genomic instability, aberrant gene expression and uncontrolled cell proliferation. 

Our lab investigates the molecular mechanisms of the replication stress response and the DNA damage response. We are also interested in an RNA surveillance pathway called nonsense-mediated RNA decay (NMD) and its interplay with DNA surveillance mechanisms. We utilize a combination of cell biological, biochemical and imaging approaches and techniques to decipher key mechanisms of the DNA/RNA surveillance networks with the goal to improve the understanding and treatment of cancer.


News

October 1, 2024

Yutong Geng has joined our lab for her rotation. Welcome, Yutong!

September 9, 2024

Mark Ma has joined our lab for undergraduate research. Welcome Mark!

April 12, 2024

Our third paper on the cytoDNA/STING/TRPV2/Ca2+-dependent signaling pathway for genome protection has been accepted by Nature Communications for publication. Congratulations to Lingzhen, Chen, Shan and the other co-authors!

January 16, 2024

Helen Yu and Pierre Sun have joined us for undergraduate research. Welcome, Helen and Pierre!

November 1, 2023

Hsiang-Ting Lu has joined us as a Laboratory Technician II. Welcome aboard, Hisang-Ting!

Affiliations

Funding